effect of gold nanoparticles on prostate dose distribution under ir-192 internal and 18 mv external radiotherapy procedures using gel dosimetry and monte carlo method
نویسندگان
چکیده
background: gel polymers are considered as new dosimeters for determining radiotherapy dose distribution in three dimensions. objective: the ability of a new formulation of magic-f polymer gel was assessed by experimental measurement and monte carlo (mc) method for studying the effect of gold nanoparticles (gnps) in prostate dose distributions under the internal ir-192 and external 18mv radiotherapy practices. method: a plexiglas phantom was made representing human pelvis. the gnp shaving 15 nm in diameter and 0.1 mm concentration were synthesized using chemical reduction method. then, a new formulation of magic-f gel was synthesized. the fabricated gel was poured in the tubes located at the prostate (with and without the gnps) and bladder locations of the phantom. the phantom was irradiated to an ir-192 source and 18 mv beam of a varian linac separately based on common radiotherapy procedures used for prostate cancer. after 24 hours, the irradiated gels were read using a siemens 1.5 tesla mri scanner. the absolute doses at the reference points and isodose curves resulted from the experimental measurement of the gels and mc simulations following the internal and external radiotherapy practices were compared. results: the mean absorbed doses measured with the gel in the presence of the gnps in prostate were 15% and 8 % higher than the corresponding values without the gnps under the internal and external radiation therapies, respectively. mc simulations also indicated a dose increase of 14 % and 7 % due to presence of the gnps, for the same experimental internal and external radiotherapy practices, respectively. conclusion: there was a good agreement between the dose enhancement factors (defs) estimated with mc simulations and experiment gel measurements due to the gnps. the results indicated that the polymer gel dosimetry method as developed and used in this study, can be recommended as a reliable method for investigating the def of gnps in internal and external radiotherapy practices.
منابع مشابه
Effect of Gold Nanoparticles on Prostate Dose Distribution under Ir-192 Internal and 18 MV External Radiotherapy Procedures Using Gel Dosimetry and Monte Carlo Method
Background: Gel polymers are considered as new dosimeters for determining radiotherapy dose distribution in three dimensions.Objective: The ability of a new formulation of MAGIC-f polymer gel was assessed by experimental measurement and Monte Carlo (MC) method for studying the effect of gold nanoparticles (GNPs) in prostate dose distributions under the internal Ir-192 and external 18MV radiothe...
متن کاملEffect of Gold Nanoparticles on Prostate Dose Distribution under Ir-192 Internal and 18 MV External Radiotherapy Procedures Using Gel Dosimetry and Monte Carlo Method
BACKGROUND Gel polymers are considered as new dosimeters for determining radiotherapy dose distribution in three dimensions. OBJECTIVE The ability of a new formulation of MAGIC-f polymer gel was assessed by experimental measurement and Monte Carlo (MC) method for studying the effect of gold nanoparticles (GNPs) in prostate dose distributions under the internal Ir-192 and external 18MV radioth...
متن کاملInvestigation of the gold nanoparticles effects on the prostate dose distribution in brachytherapy: gel dosimetry and Monte Carlo method
PURPOSE In this work, gold nanoparticles (GNPs) were embedded in the MAGIC-f polymer gel irradiated with the 192Ir brachytherapy sources. MATERIAL AND METHODS At the first plexiglas phantom was made as the human pelvis. The GNPs were synthesized with 15 nm in diameter and 0.1 mM (0.0197 mg/ml) in concentration by using a chemical reduction method. Then, the MAGIC-f gel was synthesized. The fa...
متن کاملGel dosimetry: The effect of gold nanoparticles on the dose enhancement in the external radiation therapy
Background: Normoxic type MAGICA gel dosimeters are established for dose quantification in three dimensions for radiotherapy. Objective(s): The ability of MAGICA polymer gel was assessed by experimental measurements method for studying the effect of gold nanoparticles (GNPs) in dose enhancement under the external 18MV radiotherapy practices. <...
متن کاملInvestigation and Comparison of Metal Nanoparticles on Dose Enhancement Effect in Radiotherapy Using Monte Carlo Simulation Method
Introduction: The main goal of radiation therapy is destroying the tumor so that the surrounded healthy tissues have received the least amount of radiation at the same time. In recent years, the use of nanoparticles has received much attention due to the increasing effects they can have on the deposited dose into the cancer cells. The aim of this study was to investigate the effects of nanopart...
متن کاملDosimetric investigation of high dose rate Ir-192 source with Monte Carlo method
Background: This study aims to calculate the air-kerma strength (SK), the dose rate constant (∧) and the dose rate profiles of a Gammamed 12i Ir-192 source by using the Monte Carlo technique and to compare the dose rate values with those calculated by the Abacus HDR treatment planning system (TPS). Materials and Methods: Air-kerma strength (in units of U; 1 U= μGy m2 h-1) and the dose ra...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
journal of biomedical physics and engineeringجلد ۵، شماره ۱ Mar، صفحات ۰-۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023